[PvK]

Unless there's an exceptional item, my close combat weapon is either a knife or a sword. Usually a knife, because the speed modifier affects speed when moving and shooting ranged weapons, too.

Ranged weapon depends on the situation, and what's the best available example. Multiplying swarms call for a strong enough weapon with some good adj to it. Later in the game, often I find a mortar is so destructive that it works in practically all ranges and situations. Though there are some situations where 0 adj is best. I don't think I've ever chosen a Cloud Gun.