[Rollo]

After the next patch it will be easier to use more than two weapons for designs, since you can use custom abilities and add weapons as misc. components.

To answer the original question: no, the first two designs cannot be done right now in unmodded SE4.

The third design can be done as follows:

Name := Attack Ship (CR)
Design Type := Attack Ship
Vehicle Type := Ship
Default Strategy := Optimal Firing Range
Size Minimum Tonnage := 490
Size Maximum Tonnage := 510
Num Must Have At Least 1 Ability := 0
Must Have Ability 1 := Weapon
...
Majority Weapon Family Pick 1 := 22
Majority Weapon Family Pick 2 := ...
...
Secondary Weapon Family Pick 1 := 1
Secondary Weapon Family Pick 2 := ...
...
Majority Comp Spaces Per One := 10000
Majority Comp Ability := Weapon
Secondary Comp Spaces Per One := 250 (for 2x APB) / 166 (for 3x APB)
Secondary Comp Ability := Weapon
...