[Suicide Junkie]

Having a mix of good, supply sapping weapons, and not-so-good, supply-saving weapons can come in handy.

You can then have customized defense ships, slinging thousands of supplies per turn into the combat while sitting in orbit of a resupply depot.

On the other hand, your attack ships will have to use the supply-saving weapons in order to fight more than one or two big combats.
You could also have some attack ships clear a path to the enemy lines, and bring in the powerful defense ships to back them up for a single major warppoint or homeworld battle.