Well, I also had Daemon tools lite on that comp. As for ruining the FO series... well I hadn't played the first two, so I wouldn't know, but I still felt that the game model was far better suited to Oblivion.
I put Martigen's Mutant Mod and a few others to make it more atmospheric and I blue screen every 30 minutes when I'm walking around the wasteland, and randomly when I try to save. This doesn't help the discussion at all, but I just wanted to vent. Damn Fallout3.