I was simming a battle with P&N V1.5p.
With one 
BlackHole Class Combat Fortress (which has 6120 hitpoints in Hardened bulkheads (92% absorption)), going up against Phong DNs.
As expected, the shields held out long enough for me to take down one DN, and I disabled a second before my shield grid was destroyed.
Now I started taking internal damage.  two HEMs slam me, but the HBs worked great, blocking most of the damage, and all I really lost was a single engine.  Now I was slower than the enemy, but with good ranged weapons, I could still reach out and touch someone.  Another Phong DN went down, and I took 1500 damage, losing only a PDC and one Polaron Cannon.  I'd managed to rip apart most of the shields on the Last DN, but then they got a lucky hit, and my Talisman was destroyed.  5% chance to hit at range 4, and the enemy would not let me get that close.  I spent 12 more combat turns absorbing bLast after bLast, but then combat ended.  I had taken 6500 out of 8000 damage, and would have been stuck in spacedock for around 2 years 
 
The moral of this story:  on a $100,000 dreadnaught, put a backup talisman on!
Also, the 50kT combination of MC, bridge, LS, CQ, helps a lot.  You can lose any one of the components, and not lose your ship.